The second Elser number of a connected graph. For a connected graph $G$ the $k$-th Elser number is $$ els_k(G) = (-1)^{|V(G)|+1} \sum_N (-1)^{|E(N)|} |V(N)|^k $$ where the sum is over all nuclei of $G$, that is, the connected subgraphs of $G$ whose vertex set is a vertex cover of $G$. It is clear that this number is even. It was shown in [1] that it is non-negative.

The second largest eigenvalue of a graph if it is integral. This statistic is undefined if the second largest eigenvalue of the graph is not integral. Chapter 4 of [1] provides lots of context.

The largest eigenvalue of a graph if it is integral. If a graph is $d$-regular, then its largest eigenvalue equals $d$. One can show that the largest eigenvalue always lies between the average degree and the maximal degree. This statistic is undefined if the largest eigenvalue of the graph is not integral.

The energy of a graph, if it is integral. The energy of a graph is the sum of the absolute values of its eigenvalues. This statistic is only defined for graphs with integral energy. It is known, that the energy is never an odd integer [2]. In fact, it is never the square root of an odd integer [3]. The energy of a graph is the sum of the energies of the connected components of a graph. The energy of the complete graph $K_n$ equals $2n-2$. For this reason, we do not define the energy of the empty graph.

The Frankl number of a lattice. For a lattice $L$ on at least two elements, this is $$ \max_x(|L|-2|[x, 1]|), $$ where we maximize over all join irreducible elements and $[x, 1]$ denotes the interval from $x$ to the top element. Frankl's conjecture asserts that this number is non-negative, and zero if and only if $L$ is a Boolean lattice.

The number of minimal elements in a poset.